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sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data - Nature Methods

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sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data - Nature Methods

Class-switch recombination (CSR) is an integral part of B cell maturation. Here we present sciCSR (pronounced 'scissor', single-cell inference of class-switch recombination), a computational pipeline that analyzes CSR events and dynamics of B cells from single-cell RNA sequencing (scRNA-seq) experiments. Validated on both simulated and real data, sciCSR re-analyzes scRNA-seq alignments to differentiate productive heavy-chain immunoglobulin transcripts from germline 'sterile' transcripts.

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sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data - Nature Methods

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sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data - Nature Methods

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