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Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix - Nature Cardiovascular Research

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Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix - Nature Cardiovascular Research

Myocardial passive stiffness is crucial for the heart's pump function and is determined by mechanical elements, including the extracellular matrix and cytoskeletal filaments; however, their individual contributions are controversially discussed and difficult to quantify. In this study, we targeted the cytoskeletal filaments in a mouse model, which enables the specific, acute and complete cleavage of the sarcomeric titin springs.

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Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix - Nature Cardiovascular Research

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Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix - Nature Cardiovascular Research

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