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Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming - npj Regenerative Medicine

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Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming - npj Regenerative Medicine

In optic neuropathies, including glaucoma, retinal ganglion cells (RGCs) die. Cell transplantation and endogenous regeneration offer strategies for retinal repair, however, developmental programs required for this to succeed are incompletely understood. To address this, we explored cellular reprogramming with transcription factor (TF) regulators of RGC development which were integrated into human pluripotent stem cells (PSCs) as inducible gene cassettes.

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Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming - npj Regenerative Medicine

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Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming - npj Regenerative Medicine

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