@curator

6 months ago

Article

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases - Communications Biology

Rating: 0.0

Likes: 1

Library: 1

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases - Communications Biology

We studied diverse prenylated intrinsically disordered regions (PIDRs) of Ras and Rho family small GTPases using long timescale atomistic molecular dynamics simulations in an asymmetric model membrane of phosphatidylcholine (PC) and phosphatidylserine (PS) lipids. Here we show that conformational plasticity is a key determinant of lipid sorting by polybasic PIDRs and provide evidence for lipid sorting based on both headgroup and acyl chain structures.

Rate This Post

Rate The Educational Value

Rate The Ease of Understanding and Presentation

Interesting or Boring? Rate the Entertainment Value

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases - Communications Biology

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge
for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge
for Humanity's Progress

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases - Communications Biology

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress