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Catalytic desymmetrization reactions to synthesize all-carbon quaternary stereocentres - Nature Synthesis

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Catalytic desymmetrization reactions to synthesize all-carbon quaternary stereocentres - Nature Synthesis

The term all-carbon quaternary stereocentre refers to a chiral carbon atom featuring four different carbon substituents. Such structural motifs are prominent in natural products, drugs and bioactive compounds. Incorporating such conformationally constrained stereocentres into molecules allows the exploration of chemical spaces with enhanced potency, selectivity and other drug-related properties.

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Catalytic desymmetrization reactions to synthesize all-carbon quaternary stereocentres - Nature Synthesis

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Catalytic desymmetrization reactions to synthesize all-carbon quaternary stereocentres - Nature Synthesis

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