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Cryo-EM structure of the human cardiac myosin filament - Nature

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Cryo-EM structure of the human cardiac myosin filament - Nature

Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac myosin-binding protein C (cMyBP-C), which modulates contractility in response to physiological stimuli, and titin, which functions as a scaffold for filament assembly1. Myosin, cMyBP-C and titin are all subject to mutation, which can lead to heart failure.

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Cryo-EM structure of the human cardiac myosin filament - Nature

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Cryo-EM structure of the human cardiac myosin filament - Nature

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