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Mechanism of histone H2B monoubiquitination by Bre1 - Nature Structural & Molecular Biology

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Mechanism of histone H2B monoubiquitination by Bre1 - Nature Structural & Molecular Biology

Monoubiquitination of histone H2B-K120/123 plays several roles in regulating transcription, DNA replication and the DNA damage response. The structure of a nucleosome in complex with the dimeric RING E3 ligase Bre1 reveals that one RING domain binds to the nucleosome acidic patch, where it can position the E2 ubiquitin conjugating enzyme Rad6, while the other RING domain contacts the DNA.

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Mechanism of histone H2B monoubiquitination by Bre1 - Nature Structural & Molecular Biology

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Mechanism of histone H2B monoubiquitination by Bre1 - Nature Structural & Molecular Biology

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