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Mechanical disengagement of the cohesin ring - Nature Structural & Molecular Biology

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Mechanical disengagement of the cohesin ring - Nature Structural & Molecular Biology

Cohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping DNA and counteracting the forces generated by the mitotic spindle. Whether individual cohesins encircle both sister DNAs and how cohesin opposes spindle-generated forces remains unknown. Here we perform force measurements on individual yeast cohesin complexes either bound to DNA or holding together two DNAs. By covalently closing the hinge and Smc3Psm3–kleisin interfaces we

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Mechanical disengagement of the cohesin ring - Nature Structural & Molecular Biology

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Mechanical disengagement of the cohesin ring - Nature Structural & Molecular Biology

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