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Targeting pancreatic cancer metabolic dependencies through glutamine antagonism - Nature Cancer

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Targeting pancreatic cancer metabolic dependencies through glutamine antagonism - Nature Cancer

Pancreatic ductal adenocarcinoma (PDAC) cells use glutamine (Gln) to support proliferation and redox balance. Early attempts to inhibit Gln metabolism using glutaminase inhibitors resulted in rapid metabolic reprogramming and therapeutic resistance. Here, we demonstrated that treating PDAC cells with a Gln antagonist, 6-diazo-5-oxo-l-norleucine (DON), led to a metabolic crisis in vitro.

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Targeting pancreatic cancer metabolic dependencies through glutamine antagonism - Nature Cancer

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Targeting pancreatic cancer metabolic dependencies through glutamine antagonism - Nature Cancer

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