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Gut microbiome-derived ammonia modulates stress vulnerability in the host - Nature Metabolism

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Gut microbiome-derived ammonia modulates stress vulnerability in the host - Nature Metabolism

Ammonia has been long recognized as a metabolic waste product with well-known neurotoxic effects. However, little is known about the beneficial function of endogenous ammonia. Here, we show that gut ammonia links microbe nitrogen metabolism to host stress vulnerability by maintaining brain glutamine availability in male mice. Chronic stress decreases blood ammonia levels by altering gut urease-positive microbiota.

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Gut microbiome-derived ammonia modulates stress vulnerability in the host - Nature Metabolism

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Gut microbiome-derived ammonia modulates stress vulnerability in the host - Nature Metabolism

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