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Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis - Nature Metabolism

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Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis - Nature Metabolism

Metabolic regulation is integral to the proper functioning of innate lymphoid cells, yet the underlying mechanisms remain elusive. Here, we show that disruption of exogenous proline uptake, either through dietary restriction or by deficiency of the proline transporter Slc6a7, in lymphoid tissue inducer (LTi) cells, impairs LTi activation and aggravates dextran sodium sulfate-induced colitis in mice.

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Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis - Nature Metabolism

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Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis - Nature Metabolism

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