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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection - Nature Structural & Molecular Biology

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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection - Nature Structural & Molecular Biology

Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial tetrameric protein complex. Although inorganic phosphate (Pi) is known to promote GLS filamentation and activation, the molecular basis of this mechanism is unknown. Here we aimed to determine the molecular mechanism of Pi-induced mouse GLS filamentation and its impact on mitochondrial physiology.

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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection - Nature Structural & Molecular Biology

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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection - Nature Structural & Molecular Biology

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