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Structure of LRRK1 and mechanisms of autoinhibition and activation - Nature Structural & Molecular Biology

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Structure of LRRK1 and mechanisms of autoinhibition and activation - Nature Structural & Molecular Biology

Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, their disease associations are strikingly different: LRRK2 is involved in familial Parkinson's disease while LRRK1 is linked to bone diseases.

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Structure of LRRK1 and mechanisms of autoinhibition and activation - Nature Structural & Molecular Biology

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Structure of LRRK1 and mechanisms of autoinhibition and activation - Nature Structural & Molecular Biology

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