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Deoxyfluorination of phenols for chemoselective 18F-labeling of peptides - Nature Protocols

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Deoxyfluorination of phenols for chemoselective 18F-labeling of peptides - Nature Protocols

The challenge of forming C–18F bonds is often a bottleneck in the development of new 18F-labeled tracer molecules for noninvasive functional imaging studies using positron emission tomography (PET). Nucleophilic aromatic substitution is the most widely employed reaction to functionalize aromatic substrates with the radioactive fluorine-18 but its scope is restricted to arenes containing electron-withdrawing substituents.

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Deoxyfluorination of phenols for chemoselective 18F-labeling of peptides - Nature Protocols

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Deoxyfluorination of phenols for chemoselective 18F-labeling of peptides - Nature Protocols

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