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Innate immune mechanisms mediate loss of corticostriatal synapses in Huntington's disease - Nature Medicine

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Innate immune mechanisms mediate loss of corticostriatal synapses in Huntington's disease - Nature Medicine

By analyzing human samples and multiple mouse models of Huntington's disease, we found that complement proteins and microglia mediate early and selective loss of corticostriatal synapses. Strategies that block this process can reduce synaptic loss, increase excitatory input to the striatum and prevent the development of cognitive deficits in mice.

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Innate immune mechanisms mediate loss of corticostriatal synapses in Huntington's disease - Nature Medicine

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Innate immune mechanisms mediate loss of corticostriatal synapses in Huntington's disease - Nature Medicine

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