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Activation of human STING by a molecular glue-like compound - Nature Chemical Biology

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Activation of human STING by a molecular glue-like compound - Nature Chemical Biology

Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its antitumor activity. The activation of STING requires its high-order oligomerization, which could be induced by binding of the endogenous ligand, cGAMP, to the cytosolic ligand-binding domain.

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Activation of human STING by a molecular glue-like compound - Nature Chemical Biology

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Activation of human STING by a molecular glue-like compound - Nature Chemical Biology

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