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Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation - Communications Biology

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Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation - Communications Biology

Little is known about the signaling network responsible for the organization of the perinuclear actin cap, a recently identified structure holding unique roles in the regulation of nuclear shape and cell directionality. In cancer cells expressing a constitutively active MET, we show a rearrangement of the actin cap filaments, which crash into perinuclear patches associated with spherical nuclei, meandering cell motility and inactivation of the mechano-transducer YAP1.

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Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation - Communications Biology

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Aberrant MET activation impairs perinuclear actin cap organization with YAP1 cytosolic relocation - Communications Biology

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