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Membrane curvature drives the formation of integrin adhesions on soft ECM fibres - Nature Cell Biology

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Membrane curvature drives the formation of integrin adhesions on soft ECM fibres - Nature Cell Biology

The fibrous geometry of extracellular matrices (ECMs) is believed to facilitate cell adhesion, but a mechanistic link is lacking. We uncover a type of integrin-mediated cell adhesion — 'curved adhesion' — driven by the fibrous geometry of the ECM. Curved adhesions are induced by membrane curvature, enabling cell adhesion to soft three-dimensional (3D) ECM fibres.

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Membrane curvature drives the formation of integrin adhesions on soft ECM fibres - Nature Cell Biology

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Membrane curvature drives the formation of integrin adhesions on soft ECM fibres - Nature Cell Biology

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