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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family - Nature Communications

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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family - Nature Communications

Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited (GE) chickens containing two ANP32A amino acid substitutions that prevent viral polymerase interaction. After IAV challenge, 9/10 edited chickens remain uninfected. Challenge with a higher dose, however, led to breakthrough infections.

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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family - Nature Communications

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Creating resistance to avian influenza infection through genome editing of the ANP32 gene family - Nature Communications

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