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Structure of native chromatin fibres revealed by Cryo-ET in situ - Nature Communications

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Structure of native chromatin fibres revealed by Cryo-ET in situ - Nature Communications

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA replication and repair, and chromosome segregation. This structure, however, remains elusive. Here, using cryo-FIB and cryo-ET, we delineate the 3D architecture of native chromatin fibres in intact interphase human T-lymphoblasts and determine the in situ structures of nucleosomes in different conformations.

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Structure of native chromatin fibres revealed by Cryo-ET in situ - Nature Communications

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Structure of native chromatin fibres revealed by Cryo-ET in situ - Nature Communications

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