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ERMAP activates phagocytosis in Kupffer cells to restrict liver metastases - Nature Immunology

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ERMAP activates phagocytosis in Kupffer cells to restrict liver metastases - Nature Immunology

Kupffer cells, hepatic resident macrophages, are the first line of defense against liver metastases by engulfing disseminated malignant cells. We found that ERMAP expressed on tumor cells binds to galectin-9 and dectin-2 on Kupffer cells to deliver pro-phagocytosis 'eat me' signals to Kupffer cells to restrict liver metastases.

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ERMAP activates phagocytosis in Kupffer cells to restrict liver metastases - Nature Immunology

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ERMAP activates phagocytosis in Kupffer cells to restrict liver metastases - Nature Immunology

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