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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease - Nature Medicine

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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease - Nature Medicine

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia despite the ubiquitous expression of mutant huntingtin. The molecular mechanisms underlying this region-specific neuronal degeneration and how these relate to the development of early cognitive phenotypes are poorly understood.

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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease - Nature Medicine

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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease - Nature Medicine

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