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Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells - Nature Protocols

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Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells - Nature Protocols

Kidney organoids derived from human pluripotent stem cells (hPSCs) are now being used as models of renal disease and nephrotoxicity screening. However, the proximal tubules (PTs), which are responsible for most kidney reabsorption functions, remain immature in kidney organoids with limited expression of critical transporters essential for nephron functionality.

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Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells - Nature Protocols

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Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells - Nature Protocols

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