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The great escape — how inorganic phosphate is released from actin filaments - Nature Structural & Molecular Biology

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The great escape — how inorganic phosphate is released from actin filaments - Nature Structural & Molecular Biology

The release of inorganic phosphate (Pi) from actin marks old actin filaments for disassembly. By combining cryo-electron microscopy (cryo-EM) with in vitro reconstitution and molecular dynamics simulations, we show how actin filaments release Pi through a 'molecular backdoor' and demonstrate that this arrangement is distorted in a disease-linked actin variant.

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The great escape — how inorganic phosphate is released from actin filaments - Nature Structural & Molecular Biology

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The great escape — how inorganic phosphate is released from actin filaments - Nature Structural & Molecular Biology

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