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A high throughput screen for pharmacological inhibitors of the carbohydrate response element - Scientific Data

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A high throughput screen for pharmacological inhibitors of the carbohydrate response element - Scientific Data

A central regulator of metabolism, transcription factor carbohydrate response element binding protein (ChREBP) senses and responds to dietary glucose levels by stimulating the transcription of glycolytic and lipogenic enzymes. Genetic depletion of ChREBP rescues β-cell dysfunction arising from high glucose levels, suggesting that inhibiting ChREBP might represent an attractive therapeutic approach to manage diabetes and other metabolic diseases.

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A high throughput screen for pharmacological inhibitors of the carbohydrate response element - Scientific Data

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A high throughput screen for pharmacological inhibitors of the carbohydrate response element - Scientific Data

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