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Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis - Nature Cell Biology

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Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis - Nature Cell Biology

Bone marrow endothelial cells (BMECs) play a key role in bone formation and haematopoiesis. Although recent studies uncovered the cellular taxonomy of stromal compartments in the bone marrow (BM), the complexity of BMECs is not fully characterized. In the present study, using single-cell RNA sequencing, we defined a spatial heterogeneity of BMECs and identified a capillary subtype, termed type S (secondary ossification) endothelial cells (ECs), exclusively existing in the epiphysis.

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Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis - Nature Cell Biology

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Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis - Nature Cell Biology

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