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Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis - Nature Cell Biology

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Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis - Nature Cell Biology

Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain poorly understood. Here, using intracranial injections in mice and assembloids between SCLC aggregates and human cortical organoids in culture, we found that SCLC cells recruit reactive astrocytes to the tumour microenvironment.

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Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis - Nature Cell Biology

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Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis - Nature Cell Biology

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