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Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in gene amygdala GABAergic inhibition - Nature Neuroscience
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The amygdala processes positive and negative valence and contributes to addiction, but the cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of single-nucleus gene expression and chromatin accessibility in the amygdala of outbred rats with high and low cocaine addiction-like behaviors following prolonged abstinence. Differentially expressed genes between the high and low groups were enriched for energy metabolism across cell types.
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