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Inhibition of fatty acid oxidation enables heart regeneration in adult mice - Nature

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Inhibition of fatty acid oxidation enables heart regeneration in adult mice - Nature

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration1,2. Here, to explore whether metabolic reprogramming can overcome this barrier and enable heart regeneration, we abrogate fatty acid oxidation in cardiomyocytes by inactivation of Cpt1b. We

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Inhibition of fatty acid oxidation enables heart regeneration in adult mice - Nature

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Inhibition of fatty acid oxidation enables heart regeneration in adult mice - Nature

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