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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain - npj Parkinson's Disease

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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain - npj Parkinson's Disease

Aggregation of α-synuclein (α-syn) is the cornerstone of neurodegenerative diseases termed synucleinopathies, which include Parkinson's Disease (PD), Dementia with Lewy Bodies (DLB), and Multiple System Atrophy (MSA). These synucleinopathies are characterized by the deposit of aggregated α-syn in intracellular inclusions observable in neurons and glial cells. In PD and DLB, these aggregates, predominantly located in neurons, are called Lewy Bodies (LBs).

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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain - npj Parkinson's Disease

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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain - npj Parkinson's Disease

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