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Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan - Nature Immunology

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Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan - Nature Immunology

CD8+ T cells provide robust antiviral immunity, but how epitope-specific T cells evolve across the human lifespan is unclear. Here we defined CD8+ T cell immunity directed at the prominent influenza epitope HLA-A*02:01-M158–66 (A2/M158) across four age groups at phenotypic, transcriptomic, clonal and functional levels. We identify a linear differentiation trajectory from newborns to children then adults, followed by divergence and a clonal reset in older adults.

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Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan - Nature Immunology

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Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan - Nature Immunology

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