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β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR - Nature Chemical Biology

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β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR - Nature Chemical Biology

Many G protein-coupled receptors (GPCRs) initiate a second phase of stimulatory heterotrimeric G protein (Gs)-coupled cAMP signaling after endocytosis. The prevailing current view is that the endosomal signal is inherently β-arrestin-dependent because β-arrestin is necessary for receptor internalization and, for some GPCRs, to prolong the endosomal signal.

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β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR - Nature Chemical Biology

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β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR - Nature Chemical Biology

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