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Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments - Nature Structural & Molecular Biology

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Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments - Nature Structural & Molecular Biology

The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their regulated turnover, which is fundamental to many cellular functions. The mechanisms underlying Pi release from the core and barbed end of actin filaments remain unclear. Here, using human and bovine actin isoforms, we combine cryo-EM with molecular-dynamics simulations and in vitro reconstitution to demonstrate how actin releases Pi through a 'molecular backdoor'. While constantly

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Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments - Nature Structural & Molecular Biology

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Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments - Nature Structural & Molecular Biology

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