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Iron drives anabolic metabolism through active histone demethylation and mTORC1 - Nature Cell Biology

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Iron drives anabolic metabolism through active histone demethylation and mTORC1 - Nature Cell Biology

All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here we report a previously undescribed eukaryotic pathway for iron sensing in which molecular iron is required to sustain active histone demethylation and maintain the expression of critical components of the pro-anabolic mTORC1 pathway.

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Iron drives anabolic metabolism through active histone demethylation and mTORC1 - Nature Cell Biology

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Iron drives anabolic metabolism through active histone demethylation and mTORC1 - Nature Cell Biology

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