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Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore - Nature Methods

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Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore - Nature Methods

Natural proteins are composed of 20 proteinogenic amino acids and their post-translational modifications (PTMs). However, due to the lack of a suitable nanopore sensor that can simultaneously discriminate between all 20 amino acids and their PTMs, direct sequencing of protein with nanopores has not yet been realized. Here, we present an engineered hetero-octameric Mycobacterium smegmatis porin A (MspA) nanopore containing a sole Ni2+ modification.

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Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore - Nature Methods

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Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore - Nature Methods

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