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A H3K27M-targeted vaccine in adults with diffuse midline glioma - Nature Medicine

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A H3K27M-targeted vaccine in adults with diffuse midline glioma - Nature Medicine

Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice. Here we describe a first-in-human treatment with H3K27M-vac of eight adult patients with progressive H3K27M+ diffuse midline glioma on a compassionate use basis.

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A H3K27M-targeted vaccine in adults with diffuse midline glioma - Nature Medicine

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A H3K27M-targeted vaccine in adults with diffuse midline glioma - Nature Medicine

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