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FOXO transcription factors as mediators of stress adaptation - Nature Reviews Molecular Cell Biology

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FOXO transcription factors as mediators of stress adaptation - Nature Reviews Molecular Cell Biology

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16, which gained notoriety for its capability to double lifespan in the absence of daf-2 (the gene encoding the worm insulin receptor homologue). Since then, research has provided many mechanistic details on FOXO regulation and FOXO activity.

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FOXO transcription factors as mediators of stress adaptation - Nature Reviews Molecular Cell Biology

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FOXO transcription factors as mediators of stress adaptation - Nature Reviews Molecular Cell Biology

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