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Reductive carboxylation epigenetically instructs T cell differentiation - Nature

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Reductive carboxylation epigenetically instructs T cell differentiation - Nature

Protective immunity against pathogens or cancer is mediated by the activation and clonal expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid proliferation and effector functions, naive T cells switch their quiescent metabolism to an anabolic metabolism through increased levels of aerobic glycolysis, but also through mitochondrial metabolism and oxidative phosphorylation, generating energy and signalling molecules1–3.

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Reductive carboxylation epigenetically instructs T cell differentiation - Nature

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Reductive carboxylation epigenetically instructs T cell differentiation - Nature

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