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Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis - Nature Immunology

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Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis - Nature Immunology

Iron metabolism is pivotal for cell fitness in the mammalian host; however, its role in group 3 innate lymphoid cells (ILC3s) is unknown. Here we show that transferrin receptor CD71 (encoded by Tfrc)-mediated iron metabolism cell-intrinsically controls ILC3 proliferation and host protection against Citrobacter rodentium infection and metabolically affects mitochondrial respiration by switching of oxidative phosphorylation toward glycolysis.

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Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis - Nature Immunology

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Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis - Nature Immunology

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