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New pieces for the Lis1–dynein puzzle - Nature Structural & Molecular Biology

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New pieces for the Lis1–dynein puzzle - Nature Structural & Molecular Biology

The microtubule motor dynein is regulated by lissencephaly-1 (Lis1) at several points during its complex activation process. Two papers reveal the molecular mechanism for two steps: the beginning, when Lis1 acts as a wedge to disrupt dynein's autoinhibited conformation; and the end, when microtubule binding ejects Lis1 from the motor.

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New pieces for the Lis1–dynein puzzle - Nature Structural & Molecular Biology

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