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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome - Nature

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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome - Nature

Inflammasome sensors detect pathogen- and danger-associated molecular patterns and promote inflammation and pyroptosis1. NLRP1 was the first inflammasome sensor to be described, and its hyperactivation is linked to autoinflammatory disease and cancer2–6. However, the mechanism underlying the activation and regulation of NLRP1 has not been clearly elucidated4,7,8.

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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome - Nature

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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome - Nature

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