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The laminin–keratin link shields the nucleus from mechanical deformation and signalling - Nature Materials

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The laminin–keratin link shields the nucleus from mechanical deformation and signalling - Nature Materials

The mechanical properties of the extracellular matrix dictate tissue behaviour. In epithelial tissues, laminin is a very abundant extracellular matrix component and a key supporting element. Here we show that laminin hinders the mechanoresponses of breast epithelial cells by shielding the nucleus from mechanical deformation. Coating substrates with laminin-111—unlike fibronectin or collagen I—impairs cell response to substrate rigidity and YAP nuclear localization.

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The laminin–keratin link shields the nucleus from mechanical deformation and signalling - Nature Materials

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The laminin–keratin link shields the nucleus from mechanical deformation and signalling - Nature Materials

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