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DNAzyme-based faithful probing and pulldown to identify candidate biomarkers of low abundance - Nature Chemistry

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DNAzyme-based faithful probing and pulldown to identify candidate biomarkers of low abundance - Nature Chemistry

Biomarker discovery is essential for the understanding, diagnosis, targeted therapy and prognosis assessment of malignant diseases. However, it remains a huge challenge due to the lack of sensitive methods to identify disease-specific rare molecules. Here we present MORAC, molecular recognition based on affinity and catalysis, which enables the effective identification of candidate biomarkers with low abundance.

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DNAzyme-based faithful probing and pulldown to identify candidate biomarkers of low abundance - Nature Chemistry

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DNAzyme-based faithful probing and pulldown to identify candidate biomarkers of low abundance - Nature Chemistry

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