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Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase - Nature Chemical Biology

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Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase - Nature Chemical Biology

The modification of intracellular proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) moieties is a highly dynamic process that spatiotemporally regulates nearly every important cellular program. Despite its significance, little is known about the substrate recognition and regulation modes of O-GlcNAc transferase (OGT), the primary enzyme responsible for O-GlcNAc addition.

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Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase - Nature Chemical Biology

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Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase - Nature Chemical Biology

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