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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes - Nature Chemical Biology

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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes - Nature Chemical Biology

The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific cullin modification by the ubiquitin-like protein NEDD8. Assessing cellular repertoires of activated CRL complexes is critical for understanding eukaryotic regulation. However, probes surveying networks controlled by site-specific ubiquitin-like protein modifications are lacking.

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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes - Nature Chemical Biology

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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes - Nature Chemical Biology

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