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8 months ago

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Molecular basis for potent B cell responses to antigen displayed on particles of viral size - Nature Immunology

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Molecular basis for potent B cell responses to antigen displayed on particles of viral size - Nature Immunology

Multivalent viral epitopes induce rapid, robust and T cell-independent humoral immune responses, but the biochemical basis for such potency remains incompletely understood. We take advantage of a set of liposomes of viral size engineered to display affinity mutants of the model antigen (Ag) hen egg lysozyme. Particulate Ag induces potent 'all-or-none' B cell responses that are density dependent but affinity independent.

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Molecular basis for potent B cell responses to antigen displayed on particles of viral size - Nature Immunology

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Molecular basis for potent B cell responses to antigen displayed on particles of viral size - Nature Immunology

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