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WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma - Nature Cancer

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WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma - Nature Cancer

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. β-Catenin (CTNNB1)-mutated HCC represents 30% of cases of the disease with no precision therapeutics available. Using chemical libraries derived from clinical multi-kinase inhibitor (KI) scaffolds, we screened HCC organoids to identify WNTinib, a KI with exquisite selectivity in CTNNB1-mutated human and murine models, including patient samples.

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WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma - Nature Cancer

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WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma - Nature Cancer

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