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OPA1 helical structures give perspective to mitochondrial dysfunction - Nature

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OPA1 helical structures give perspective to mitochondrial dysfunction - Nature

Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60–80% of cases1 are caused by mutations of the gene that encodes optic atrophy protein 1 (OPA1), a protein that has a key role in inner mitochondrial membrane fusion and remodelling of cristae and is crucial for the dynamic organization and regulation of mitochondria2. Mutations in OPA1 result in the dysregulation of the GTPase-mediated fusion process of the mitochondrial inner and outer membranes3.

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OPA1 helical structures give perspective to mitochondrial dysfunction - Nature

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