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Mapping the T cell repertoire to a complex gut bacterial community - Nature

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Mapping the T cell repertoire to a complex gut bacterial community - Nature

Certain bacterial strains from the microbiome induce a potent, antigen-specific T cell response1–5. However, the specificity of microbiome-induced T cells has not been explored at the strain level across the gut community. Here, we colonize germ-free mice with complex defined communities (roughly 100 bacterial strains) and profile T cell responses to each strain. The pattern of responses suggests that many T cells in the gut repertoire recognize several bacterial strains from the community.

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Mapping the T cell repertoire to a complex gut bacterial community - Nature

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Mapping the T cell repertoire to a complex gut bacterial community - Nature

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