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PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion - Nature Structural & Molecular Biology

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PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion - Nature Structural & Molecular Biology

Sister chromatid cohesion, established during replication by the ring-shaped multiprotein complex cohesin, is essential for faithful chromosome segregation. Replisome-associated proteins are required to generate cohesion by two independent pathways. One mediates conversion of cohesins bound to unreplicated DNA ahead of replication forks into cohesive entities behind them, while the second promotes cohesin de novo loading onto newly replicated DNA.

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PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion - Nature Structural & Molecular Biology

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PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion - Nature Structural & Molecular Biology

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